HIV and AIDS has caused serious impacts on sustainable development in all sectors of the economy including higher education. The need to assess risk in higher education in Africa is lacking. This piece of work adds on to existing knowledge on HIV and AIDS among higher education institutions on knowledge, attitudes and practices regarding the epidemic. An HIV and AIDS Knowledge, Attitudes and Practices analysis was conducted among university employees using a case study design. Data was collected using 100 questionnaires and 12 in-depth interviews from both academic and non academic staff and descriptive statistics were used to analyse data from questionnaires and thematic content analysis was carried out to analyse interviews. The results show that there are high knowledge levels of HIV and AIDS, STIs among both academic and non-academic staff. Reported attitudes show low risk attitudes. This however does not require that universities should not implement comprehensive HIV and AIDS programmes because the impact of the epidemic cannot be ignored.