Primary goal of day-to-day ongoing research is to optimize healing and the biggest challenges that the researchers face is the development of a regenerative biomaterial to regulate inflammation and accelerate wound healing. The key role of platelets in inflammation and wound healing is owing to the presence of several growth factors and cytokines. Platelet concentrates (PCs) typically refer to a group of materials produced from autologous blood designed to improve tissue regeneration. They provide the potential for simultaneous delivery of an abundance of bioactive molecules, including transforming growth factor beta-1 (TGF-beta1), platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and insulin-like growth factor (IGF). These PC preparations have been established as an affordable, safer and more potent way to release high concentrations of cocktails of growth factors locally for enhanced tissue regeneration.