A comprehensive review of evidence-based medicine for the food animal practitioner! Topics include: evidence-based veterinary medicine: principles, applications and perceptions in veterinary medicine, systemic review in the evidence-based veterinary medicine: material and methods, evidence related to the use of ancillary drugs in bovine respiratory disease (anti-inflammatory and others: are they justified or not?, evidence-based use of prokinetic drugs for abomasal disorders in calves and cows, what is the best therapeutic option between intramammary and systemic antibiotic treatment and between intramammary antibiotics?, evidence-based management of infectious certifiable diseases, evidence-based veterinary medicine concerning vaccinal efficiency against clostridial diseases in calves, evidence based therapeutical options for hepatic lipidosis in dairy cows : dextrose, insulin, and others?, and evidence based effectiveness concerning vaccination against mannheimia haemolytica, pasteurella multocida and histophilus somni in feedlot cattle, and much more!