This issue of Physician Assistant Clinics, guest edited by Daniel Thibodeau MHP, PA-C, DFAAPA, is devoted to Cardiology. Articles in this issue include: Hypertension: Evaluation, Management and Keeping Patients in the Safe Zone; Cardiovascular Risk and Assessment: Impact of Comorbidities to the Cardiovascular System; Arrhythmia Detection and Management; Anticoagulation: The Successes and Pitfalls of Long-term Management; Dyslipidemia: Long-term Management and Other Uses of Statins for Cardiac Disease; Acute Coronary Syndrome: Care After a Patient Event and Strategies to Improve Adherence; Evaluation of Chest Pain in the Primary Care Setting; Ischemic Heart Disease; Heart Failure and Cardiomyopathy; Pulmonary Hypertension and Thromboembolism: Long-term Management and Chronic Oral Anticoagulation; Approaches to Valvular Disease in the Primary Care Setting; and Syncope: Initial Evaluation and Workup in the Primary Care Office.