This issue of Neuroimaging Clinics of North America focuses on Ischemic Stroke, and is edited by Dr. Lotfi Hacein-Bey. Articles will include: Clinical distinction of cerebral ischemia and triaging of patients in the ED: mimics, wake-ups, late strokes and chameleons; Telestroke; CT, CTA and CT perfusion of acute stroke; MRI based imaging of acute stroke; Advanced neuroimaging of acute stroke: collaterals, permeability imaging, Arterial Spin Labeling; Penumbra, oligemia, infarction: understanding hypoperfusion with neuroimaging?; Pathophysiology of thrombus and clinical implications; Neuro-interventional management of stroke; Non interventional treatment options for stroke; What to look for on post-stroke neuroimaging; Reperfusion changes after stroke and practical approaches for neuroprotection; Economics of stroke treatment (value-based payment models and other); Health care organization of neuroradiological management of stroke at regional and national levels: the French experience; and more!