This issue of Clinics in Plastic Surgery, devoted to Complications in Breast Reduction, is guest edited by Dr. Dennis C. Hammond. Articles in this issue include: Assessing Risk and Avoiding Complications in Breast Reduction; Management of Shape Distortion After Vertical Breast Reduction; Management of Shape Distortion After Wise Pattern Breast Reduction; Management of Shape Distortion After SPAIR Mammaplasty; Management of the Ischemic NAC After Breast Reduction; Nipple Reconstruction After NAC Necrosis Following Breast Reduction; Management of Recurrent Macromastia; Management of Occult Cancer After Breast Reduction; Mammographic Management of the Post-reduction Breast; Management of Asymmetry After Breast Reduction; Management of the High Riding Nipple After Breast Reduction; Breast Reduction in the Burned Breast; Avoiding Complications in Gigantomastia; and Avoiding Medicolegal Risk in Breast Reduction.