This issue of Dental Clinics of North America focuses on Clinical Microbiology for the General Dentist, and is edited by Drs. Orrett Ogle and Arvind Babu Rajendra Santosh. Articles will include: Clinical microbiology for the dentist; Normal oral flora and the oral ecosystem; Bacterial, viral and fungal infections of the oral cavity; Odontogenic infections: clinical and microbiological evaluation, diagnosis, treatment and prevention; Osteomyelitis: clinical and microbiological evaluation, diagnosis, treatment and prevention; Periodontal infections; Epidemiology of oral microbial infections; Bacterial infections in oral cavity; Fungal infections in oral cavity; Viral infections in oral cavity; Immunization recommendations for the oral health professionals; Opportunistic infections in oral cavity; Microbial carcinogenesis: HPV, HIV, KSV, and EBV; Recent recommendations of HIV treatment; and more!