Diabetes mellitus (DM): is the disturbance of pancreas with decreased secretion of insulin or resistance to insulin actions by peripheral tissue which is classified as either type 1 that 1 rates from five to ten percent of the cases of DM or type 2 (TYPE 2) that counting for ninety to ninety five percent of the individuals with DM. The complications of DM patients can effects multiple vital organ systems leading to serious pathological situations like Nonalcoholic fatty liver disease (NAFLD). Cirrhosis (fibrosis): cause weaken insulin clearance by hepatocytes and also is linked with elevated concentrations of advanced-glycation-end products which the glucose constitutes covalent adducts with the proteins in plasma via a non-enzymatic procedure known as glycation. In hepatocellular carcinoma (HCC), the hyperinsulinemia, chronic inflammation and IR linked with DM and are all related to malignant tumor. There is confirmation of the elevated risk of DM in HBV patients in contrast with non HBV infected persons. Acute liver failure (ALF): Recent papers have seen the failure of liver amidst DM people that is linked by the utilization of the troglitazone that lowers the glucose in blood.