In the last decade, applications of tissue engineering technology in dental regenerative medicine have expanded enormously. In particular, the use of mesenchymal stem cells, which are highly proliferative and have the capacity to differentiate into osteogenic, chondrogenic, and adipogenic cells, promises to have a positive impact on the future of dentistry. In clinical dental therapy, several non-stem-cell based methods have been developed for periodontal and bone tissue engineering. These methods include the stimulation of regeneration using enamel matrix proteins, guided tissue regeneration, various bone grafting techniques, and the Introduction Stem Cell application of growth factors and have been applied either alone or in combination. However, there are various limitations and shortcomings in the currently available methods.