Globally, the incidence of cerebrovascular disease (stroke) is increasing every year. According to the World Stroke Organisation, "stroke is a significant cause of death and disability today. One in 6 people suffers a stroke during their lifetime. Each year, stroke affects 15 million people worldwide, 5.8 million of whom die and another 6.7 million are left disabled. The main factors in the development of stroke are components of metabolic syndrome (MS), and its presence significantly increases the risk of stroke." In the assessment of MS prevalence by WHO experts it is stated that "today the world is facing a new pandemic of the XXI century, covering industrialised countries. The monograph is devoted to one of the urgent problems of modern neurology, the probability of development and peculiarities of clinical course of multifactorial diseases are largely determined by genetic determinants. Monographs are intended for neurologists, therapists, cardiologists, general practitioners, master's and clinical residents.