This book presents the proceedings of the Triple Helix Nigeria SciBiz Conference 2025 (THN SciBiz 2025), which took place from October 15 to 17, 2025, in Abuja, Nigeria. This book is the second in a transformative annual series designed to accelerate the commercialization of research and innovation in Nigeria and beyond. The book covers topics such as infrastructure, energy, and industrialization for economic growth; science, innovation, and society: ethics, equity, and impact; digital transformation and smart technologies in business and society; university-industry-government collaboration for innovation; and sustainable entrepreneurship in the green economy. Bringing together key actors from academia, industry, and government, this book explores actionable solutions for economic transformation through interdisciplinary dialogue and knowledge exchange.